Stefan Spulber

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Alpha-MSH decreases core and brain temperature during global cerebral ischemia in rats
    Stefan Spulber
    Division of Experimental Geriatrics, Neurotec Department, Karolinska Institutet, Novum, 4th Floor, SE 141 86 Stockholm, Sweden
    Neuroreport 16:69-72. 2005
  2. ncbi request reprint Alpha-MSH rescues neurons from excitotoxic cell death
    Asa Forslin Aronsson
    Division of Neurodegeneration and Neuroinflammation, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    J Mol Neurosci 33:239-51. 2007
  3. doi request reprint Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro
    Laura Mateos
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet Alzheimer s Disease Research Center, Karolinska Institutet, Stockholm, Sweden
    Brain Pathol 19:69-80. 2009
  4. doi request reprint Connection between inflammatory processes and transmittor function-Modulatory effects of interleukin-1
    Stefan Spulber
    Department of Neurobiology, Care Sciences and Society, Division of Neurodegeneration, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Prog Neurobiol 90:256-62. 2010
  5. doi request reprint Blunted neurogenesis and gliosis due to transgenic overexpression of human soluble IL-1ra in the mouse
    Stefan Spulber
    Department of Neurobiology, Care Sciences and Society, Novum, Floor 5, Division of Neurodegeneration and Neuroinflammation, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Eur J Neurosci 27:549-58. 2008
  6. doi request reprint Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain
    Stefan Spulber
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Neuroimmunol 208:46-53. 2009
  7. pmc PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae
    Stefan Spulber
    Dept of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 9:e94227. 2014
  8. ncbi request reprint alpha-Melanocyte-stimulating hormone is neuroprotective in rat global cerebral ischemia
    Sa Forslin Aronsson
    Division of Experimental Geriatrics, Neurotec Department, Karolinska Institutet, Karolinska University Hospital, Novum, KFC, Level 4, SE 141 86 Stockholm, Sweden
    Neuropeptides 40:65-75. 2006
  9. pmc Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice
    Stefan Spulber
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e42078. 2012
  10. doi request reprint Morphological and behavioral changes induced by transgenic overexpression of interleukin-1ra in the brain
    Stefan Spulber
    Department of Neurobiology, Care Sciences and Society, Division of Neurodegeneration, Karolinska Institutet, Stockholm, Sweden
    J Neurosci Res 89:142-52. 2011

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Alpha-MSH decreases core and brain temperature during global cerebral ischemia in rats
    Stefan Spulber
    Division of Experimental Geriatrics, Neurotec Department, Karolinska Institutet, Novum, 4th Floor, SE 141 86 Stockholm, Sweden
    Neuroreport 16:69-72. 2005
    ..alpha-MSH did not influence CT or BT in sham-operated rats. The alpha-MSH-induced hypothermia and its potentiation of reduction in BT during global cerebral ischemia, may contribute to neuroprotective effects of alpha-MSH...
  2. ncbi request reprint Alpha-MSH rescues neurons from excitotoxic cell death
    Asa Forslin Aronsson
    Division of Neurodegeneration and Neuroinflammation, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    J Mol Neurosci 33:239-51. 2007
    ..Furthermore, the administration of alpha-MSH resulted in a similar increase in cell viability, supporting the hypothesis that administration of alpha-MSH has rescuing effects on neurons subjected to excitotoxic insults...
  3. doi request reprint Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro
    Laura Mateos
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet Alzheimer s Disease Research Center, Karolinska Institutet, Stockholm, Sweden
    Brain Pathol 19:69-80. 2009
    ..We propose that one of the mechanisms, by which hypercholesterolemia contributes to neurodegenerative diseases, could be through Arc down-regulation caused by 27-hydroxycholesterol...
  4. doi request reprint Connection between inflammatory processes and transmittor function-Modulatory effects of interleukin-1
    Stefan Spulber
    Department of Neurobiology, Care Sciences and Society, Division of Neurodegeneration, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Prog Neurobiol 90:256-62. 2010
    ..Moreover, deregulated expression of interleukin-1 is associated with ageing-related chronic neurodegenerative disorders...
  5. doi request reprint Blunted neurogenesis and gliosis due to transgenic overexpression of human soluble IL-1ra in the mouse
    Stefan Spulber
    Department of Neurobiology, Care Sciences and Society, Novum, Floor 5, Division of Neurodegeneration and Neuroinflammation, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Eur J Neurosci 27:549-58. 2008
    ..Taken together, our results indicate that IL-1 is crucial for the adaptability of the brain to acute and chronic neuroinflammation...
  6. doi request reprint Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain
    Stefan Spulber
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Neuroimmunol 208:46-53. 2009
    ..Together with the finding that blocking IL-1 receptors interferes with the BDNF-ERK1/2 pathway, our data suggest an essential role played by physiological levels of IL-1 in long-term memory consolidation...
  7. pmc PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae
    Stefan Spulber
    Dept of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 9:e94227. 2014
    ..In conclusion, developmental exposure to PFOS in zebrafish induces spontaneous hyperactivity mediated by a dopaminergic deficit, which can be partially reversed by dexamfetamine in zebrafish larvae. ..
  8. ncbi request reprint alpha-Melanocyte-stimulating hormone is neuroprotective in rat global cerebral ischemia
    Sa Forslin Aronsson
    Division of Experimental Geriatrics, Neurotec Department, Karolinska Institutet, Karolinska University Hospital, Novum, KFC, Level 4, SE 141 86 Stockholm, Sweden
    Neuropeptides 40:65-75. 2006
    ..Further studies will be required to define the post-ischemic time window for administration of alpha-MSH...
  9. pmc Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice
    Stefan Spulber
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e42078. 2012
    ..Taken together, our data point to the regulation of cytokine expression being an additional critical mechanism underlying the beneficial effects of molecular hydrogen...
  10. doi request reprint Morphological and behavioral changes induced by transgenic overexpression of interleukin-1ra in the brain
    Stefan Spulber
    Department of Neurobiology, Care Sciences and Society, Division of Neurodegeneration, Karolinska Institutet, Stockholm, Sweden
    J Neurosci Res 89:142-52. 2011
    ..9%). In conclusion, we show that IL-1 signalling is important for normal development of the brain, and the initial alteration resulting from prenatal exposure to IL-1ra can be recovered provided that the IL-1 signalling pathway is intact...
  11. doi request reprint Claudin expression profile separates Alzheimer's disease cases from normal aging and from vascular dementia cases
    Stefan Spulber
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurol Sci 322:184-6. 2012
    ..Our findings might be valuable in the perspective of developing biomarkers for AD...
  12. doi request reprint Prenatal exposure to PFOS or PFOA alters motor function in mice in a sex-related manner
    Natalia Onishchenko
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, Stockholm, Sweden
    Neurotox Res 19:452-61. 2011
    ..The neurobehavioral outcome of prenatal exposure to PFCs in mice is characterized by mild alterations in motor function and it appears to be sex-related...